Research

NITRIC OXIDE (NO) is one of the simplest molecules in biology, comprised of just two atoms—one atom of nitrogen (N) and one of oxygen (O). Though nitric oxide’s structure is simple, nitric oxide is now regarded as the most significant molecule in the body, one that is crucial to a person’s well-being.

Nitric oxide is a powerful signalling molecule present in the cardiovascular and nervous systems as well as throughout the rest of the body, influencing the functioning of virtually every bodily organ, including the lungs, liver, kidneys, stomach, genitals, and, of course, the heart. Among the many vital duties nitric oxide performs is its role as a vasodilator, meaning that it helps control blood flow to every part of the body. nitric oxide relaxes and enlarges the blood vessels, ensuring that blood can efficiently nourish the heart, helping to support healthy blood pressure levels. Nitric oxide also works to prevent the formation of blood clots, which can be a trigger for strokes and heart attacks, whilst slowing the accumulation of atherosclerotic plaque in the blood vessels along with supporting the immune system, combating toxins and providing a strong internal defence system. Nitric oxide therefore plays a vital role in the health of your arteries, and thus your heart and therefore your quality of general health.

The manufacture of nitric oxide takes place mainly in the endothelium— which is the layer of cells lining the interior surface of the blood vessels. Heart disease, being overweight, lack of exercise, smoking, high cholesterol, high blood pressure and high levels of homocysteine all, amongst other issues, cause damage to the endothelium. And a damaged endothelium is clearly not conducive to the production of nitric oxide, which results in more damage and an increasingly dangerous downward spiral of declining health.

A damaged endothelium is not the only issue we need to address. Whilst L-Arginine is an amino acid that can produce nitric oxide in your system, unfortunately, the amounts that we consume from our food naturally are insufficient to make the difference in nitric oxide production that is required to stimulate health benefits. Supplementation is the best way to ensure a healthy endothelium resulting in nitric oxide production at its best.


Clinical Trial Evidence for Ingredients of AF-8

Click on each ingredient below for a full description.

CLINICAL EVIDENCE FOR MAINTAINING REDUCED CHOLESTEROL WHEN TAKING AF-8
Female patient (80 years) presented with very high cholesterol (over 6.5) and was put on statins by her Doctor - which successfully reduced her cholesterol. Patient did not like taking the statins as she experienced very unpleasant side effects and so told her Doctor she was going to stop taking them. Her cholesterol went back up, so her Doctor insisted that she go back on statins again – which she did and her cholesterol came down again to 5.2. Patient asked her Doctor if she could stop the statins for 3 months and take AF-8. The Doctor agreed on the proviso he took blood tests so he could monitor and check. He took blood tests (Results-A) at the start of the 3 months, but cautioned patient that he wanted to retest her after the 3 months and if her cholesterol had gone back up again she would need to start taking statins again. After 3 months her re-test blood works (Results-B) show that not only has the cholesterol level not gone up again, it has actually dropped by a further .5 points down to 4.7. Her Doctor expressed great surprise and has asked for more information on AF-8 and has agreed the patient does not need to start taking statins again as long as she continues taking AF-8. He also advised that there were improvements in other blood test results as well, since taking AF-8.

Results A

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Results B

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